Atlas of genetics and cytogenetics in oncology and haematology home   genes   leukemias   solid tumours   cancer-prone   deep insight   case reports   journals  portal   teaching    x y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 na soft tissue tumors: malignant melanoma of soft parts identity phylum lung, heart, skin, other:melanoma:melanoma soft parts/t(12;22)(q13;q12) other names clear cell sarcoma of soft parts classification     this tumour, initially described by enzinger as "clear cell sarcoma of tendons and aponeuroses", is of uncertain origin, but its immunohistochemical profile shows its melanocytic nature; however it has no genetic relationship with the cutaneous malignant melanoma clinics and pathology embryonic origin being of melanocytic origin, this tumour should be classified as a neuroectodermal tumour etiology unknown epidemiology it is a very rare tumour representing a minority of all soft tissue sarcomas clinics the malignant melanoma of soft parts (mmsp) preferentially occurs in young adults, between ages of 20 and 40 years; the tumour develops mainly in the extremities, especially the legs (foot, knee, heel, ankle); it is usually deeply seated, and often bound to tendons and aponeuroses pathology the tumours show compact nests and strands of round or fusiform cells with a clear cytoplasm, separated by fibrocollagenous tissue often connected to adjacent tendons or aponeuroses; mitotic index is generally low; the cells of nearly all cases express s-100 protein and the melanoma-associated antigen hmb45 treatment the treatment protocols vary greatly according to the intitutions; however, the melanoma of soft parts is a highly malignant tumour which requires surgical excision combined with radiotherapy and/or chemotherapy evolution many patients develop recurrences and regional and distant metastases, in lymph nodes, lung, and bones; in the series of enzinger, the average time between diagnosis and recurrence was 2. viagra without a doctor prescription viagra use heart patients viagra for sale cheap viagra viagra on insurance cheap viagra 6 years, between diagnosis and metastasis, 3. cheap generic viagra viagra 5 mg instructions Viagra mg does come what is the difference between viagra viagra and viagra viagra use heart patients 5 years prognosis the prognosis is poor; in the series of cardinal patients studied by enzinger, 46% had died; of the 62 living patients, 21 experienced one or more recurrences, and 7 had a metastatic disease cytogenetics cytogeneticsmorphological this tumour is characterised by the presence of a chromosome translocation t(12;22)(q13;q12), which involves genes atf-1, on chromosome 12, and ews, on chromosome 22 genes involved and proteins gene name ewsr1 location 22q12 protein rna binding protein gene name atf-1 location 12q13 protein transcription factor result of the chromosomal anomaly fusion protein description the chimaeric protein is composed of the n-terminal domain of ews linked to the bzip domain of atf-1 oncogenesis binds to atf sites present in camp-responsive promoters via the atf1 bzip domain and activates transcription constitutively, dependent on the activation do. buy viagra online without script Viagra and viagra prices buy cheap viagra where to buy viagra manchester cheap generic viagra viagra use heart patients cheap viagra viagra online Viagra taken with food generic viagra cheap canada Zydeco Flames

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